Mitochondrial Inhibitor 3-Nitroproprionic Acid Enhances Oxidative Modification of Alpha-synuclein in a Transgenic Mouse Model of Multiple System Atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by autonomic failure, parkinsonism, cerebellar ataxia, and oligodendrocytic accumulation of alpha-synuclein (αsyn). Oxidative stress has been linked to neuronal death in MSA and the mitochondrial toxin 3-nitroprop...

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Hoofdauteurs: Ubhi, Kiren, Lee, Phil Hyu, Adame, Anthony, Inglis, Chandra, Mante, Michael, Rockenstein, Edward, Stefanova, Nadia, Wenning, Gregor K., Masliah, Eliezer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885901/
https://ncbi.nlm.nih.gov/pubmed/19405128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22089
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