Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology

Transgenic PDAPP mice, which express a disease-linked isoform of the human amyloid precursor protein, exhibit CNS pathology that is similar to Alzheimer's disease. In an age-dependent fashion, the mice develop plaques containing β-amyloid peptide (Aβ) and exhibit neuronal dystrophy and synaptic...

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Detalhes bibliográficos
Main Authors: Bard, Frédérique, Barbour, Robin, Cannon, Catherine, Carretto, Robert, Fox, Michael, Games, Dora, Guido, Teresa, Hoenow, Kathleen, Hu, Kang, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Celeste, Lee, Mike, Motter, Ruth, Nguyen, Minh, Reed, Amanda, Schenk, Dale, Tang, Pearl, Vasquez, Nicki, Seubert, Peter, Yednock, Ted
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149952/
https://ncbi.nlm.nih.gov/pubmed/12566568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0436286100
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