Neutralization of Soluble, Synaptotoxic Amyloid β Species by Antibodies Is Epitope Specific

Several anti-amyloid β (Aβ) antibodies are under evaluation for the treatment of Alzheimer's disease (AD). Clinical studies using the N-terminal-directed anti-Aβ antibody bapineuzumab have demonstrated reduced brain PET-Pittsburg-B signals, suggesting the reduction of Aβ plaques, and reduced le...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Zago, Wagner, Buttini, Manuel, Comery, Thomas A., Nishioka, Christopher, Gardai, Shyra J., Seubert, Peter, Games, Dora, Bard, Frédérique, Schenk, Dale, Kinney, Gene G.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621896/
https://ncbi.nlm.nih.gov/pubmed/22357853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1676-11.2012
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