A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic β-Amyloid Oligomers

BACKGROUND AND AIMS: Unnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition and inhibition. Our goal was to construct multivalent foldamer-dendrimer conjugates which wrap the synaptotoxic β-amyloid (Aβ) oligomers with high affinity throug...

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Main Authors: Fülöp, Lívia, Mándity, István M., Juhász, Gábor, Szegedi, Viktor, Hetényi, Anasztázia, Wéber, Edit, Bozsó, Zsolt, Simon, Dóra, Benkő, Mária, Király, Zoltán, Martinek, Tamás A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408453/
https://ncbi.nlm.nih.gov/pubmed/22859942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039485
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