Integration of non-SMAD and SMAD signaling in TGF-β1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells

Por Samarakoon, Rohan, Higgins, Paul J.
Publicado em 2008

Linking Cell Structure to Gene Regulation: Signaling Events and Expression Controls on the Model Genes PAI-1 and CTGF

Por Samarakoon, Rohan, Goppelt-Struebe, Margarete, Higgins, Paul J.
Publicado em 2010

TGF-β Signaling in Tissue Fibrosis: Redox Controls, Target Genes and Therapeutic Opportunities

Por Samarakoon, Rohan, Overstreet, Jessica M., Higgins, Paul J.
Publicado em 2012

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

Por Tang, Jiaqi, Gifford, Cody C., Samarakoon, Rohan, Higgins, Paul J.
Publicado no Cancers (Basel) (2018)

TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling

Por Samarakoon, Rohan, Higgins, Stephen P., Higgins, Craig E., Higgins, Paul J.
Publicado em 2008

Differential Requirement for MEK/ERK and SMAD Signaling in PAI-1 and CTGF Expression in Response to Microtubule Disruption

Por Samarakoon, Rohan, Higgins, Craig E., Higgins, Stephen P., Higgins, Paul J.
Publicado em 2009

TGF-β1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy

Por Samarakoon, Rohan, Higgins, Craig E., Higgins, Stephen P., Higgins, Paul J.
Publicado em 2009

TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

Por Samarakoon, Rohan, Overstreet, Jessica M., Higgins, Stephen P., Higgins, Paul J.
Publicado em 2011

Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity

Por Overstreet, Jessica M., Samarakoon, Rohan, Meldrum, Kirstan K., Higgins, Paul J.
Publicado em 2014

Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses

Por Overstreet, Jessica M., Samarakoon, Rohan, Cardona-Grau, Diana, Goldschmeding, Roel, Higgins, Paul J.
Publicado no FASEB J (2015)

Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

Por Samarakoon, Rohan, Chitnis, Subhanir S., Higgins, Stephen P., Higgins, Craig E., Krepinsky, Joan C., Higgins, Paul J.
Publicado em 2011

TGF-β1-Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling

Por Higgins, Stephen P., Samarakoon, Rohan, Higgins, Craig E., Freytag, Jennifer, Wilkins-Port, Cynthia E., Higgins, Paul J.
Publicado em 2009

PAI-1 Mediates the TGF-β1+EGF-Induced “Scatter” Response in Transformed Human Keratinocytes

Por Freytag, Jennifer, Wilkins-Port, Cynthia E., Higgins, Craig E., Higgins, Stephen P., Samarakoon, Rohan, Higgins, Paul J.
Publicado em 2010

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

Por Anorga, Sandybell, Overstreet, Jessica M., Falke, Lucas L., Tang, Jiaqi, Goldschmeding, Roel G., Higgins, Paul J., Samarakoon, Rohan
Publicado no FASEB J (2018)

Loss of Tumour Suppressor PTEN Expression in Renal Injury Initiates SMAD3 and p53 Dependent Fibrotic Responses

Por Samarakoon, Rohan, Helo, Sevann, Dobberfuhl, Amy D, Khakoo, Nidah S, Falke, Lucas, Overstreet, Jessica M, Goldschmeding, Roel, Higgins, Paul J
Publicado no J Pathol (2015)

SERPINE1 (PAI-1) is deposited into keratinocyte migration “trails” and required for optimal monolayer wound repair

Por Providence, Kirwin M., Higgins, Stephen P., Mullen, Andrew, Battista, Ashley, Samarakoon, Rohan, Higgins, Craig E., Wilkins-Port, Cynthia E., Higgins, Paul J.
Publicado em 2008

Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair

Por Samarakoon, Rohan, Rehfuss, Alexandra, Khakoo, Nidah S., Falke, Lucas L., Dobberfuhl, Amy D., Helo, Sevann, Overstreet, Jessica M., Goldschmeding, Roel, Higgins, Paul J.
Publicado no FASEB J (2016)

Ureteral Obstruction-Induced Renal Fibrosis: An In Vivo Platform for Mechanistic Discovery and Therapeutic Intervention

Por Dobberfuhl, Amy D., Samarakoon, Rohan, Higgins, Craig E., Mian, Badar M., Overstreet, Jessica M., Higgins, Stephen P., Kogan, Barry A., Higgins, Paul J.
Publicado em 2012

TGF-β1/p53 Signaling in Renal Fibrogenesis

Por Higgins, Stephen P., Tang, Yi, Higgins, Craig E., Mian, Badar, Zhang, Wenzheng, Czekay, Ralf-Peter, Samarakoon, Rohan, Conti, David J., Higgins, Paul J.
Publicado no Cell Signal (2017)

SERPINE1 (PAI-1) Is a Prominent Member of the Early G(0)→G(1) Transition “Wound Repair” Transcriptome in p53 Mutant Human Keratinocytes

Por Qi, Li, Higgins, Stephen P., Lu, Qi, Samarakoon, Rohan, Wilkins-Port, Cynthia E., Ye, Qunhui, Higgins, Craig E., Staiano-Coico, Lisa, Higgins, Paul J.
Publicado em 2007