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TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling

TGF-β1 and its target gene encoding plasminogen activator inhibitor-1 (PAI-1) are major causative factors in the pathology of tissue fibrosis and vascular disease. The increasing complexity of TGF-β1 action in the cardiovascular system requires analysis of specific TGF-β1-initiated signaling events...

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Detalhes bibliográficos
Main Authors: Samarakoon, Rohan, Higgins, Stephen P., Higgins, Craig E., Higgins, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394714/
https://ncbi.nlm.nih.gov/pubmed/18255094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2007.12.006
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