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Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity
Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease progression. While SMAD3 is an established pro-fibroti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4048950/ https://ncbi.nlm.nih.gov/pubmed/24613410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2014.02.017 |
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