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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

Chronic kidney disease constitutes an increasing medical burden affecting 26 million people in the United States alone. Diabetes, hypertension, ischemia, acute injury, and urological obstruction contribute to renal fibrosis, a common pathological hallmark of chronic kidney disease. Regardless of eti...

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Detalhes bibliográficos
Main Authors: Samarakoon, Rohan, Overstreet, Jessica M., Higgins, Stephen P., Higgins, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188682/
https://ncbi.nlm.nih.gov/pubmed/21638209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-011-1181-y
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