TGF-β Signaling in Tissue Fibrosis: Redox Controls, Target Genes and Therapeutic Opportunities

Por Samarakoon, Rohan, Overstreet, Jessica M., Higgins, Paul J.
Publicado em 2012

TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

Por Samarakoon, Rohan, Overstreet, Jessica M., Higgins, Stephen P., Higgins, Paul J.
Publicado em 2011

Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity

Por Overstreet, Jessica M., Samarakoon, Rohan, Meldrum, Kirstan K., Higgins, Paul J.
Publicado em 2014

Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses

Por Overstreet, Jessica M., Samarakoon, Rohan, Cardona-Grau, Diana, Goldschmeding, Roel, Higgins, Paul J.
Publicado no FASEB J (2015)

Loss of Tumour Suppressor PTEN Expression in Renal Injury Initiates SMAD3 and p53 Dependent Fibrotic Responses

Por Samarakoon, Rohan, Helo, Sevann, Dobberfuhl, Amy D, Khakoo, Nidah S, Falke, Lucas, Overstreet, Jessica M, Goldschmeding, Roel, Higgins, Paul J
Publicado no J Pathol (2015)

Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

Por Overstreet, Jessica M., Wang, Yinqiu, Wang, Xin, Niu, Aolei, Gewin, Leslie S., Yao, Bing, Harris, Raymond C., Zhang, Ming-Zhi
Publicado no FASEB J (2017)

Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair

Por Samarakoon, Rohan, Rehfuss, Alexandra, Khakoo, Nidah S., Falke, Lucas L., Dobberfuhl, Amy D., Helo, Sevann, Overstreet, Jessica M., Goldschmeding, Roel, Higgins, Paul J.
Publicado no FASEB J (2016)

Ureteral Obstruction-Induced Renal Fibrosis: An In Vivo Platform for Mechanistic Discovery and Therapeutic Intervention

Por Dobberfuhl, Amy D., Samarakoon, Rohan, Higgins, Craig E., Mian, Badar M., Overstreet, Jessica M., Higgins, Stephen P., Kogan, Barry A., Higgins, Paul J.
Publicado em 2012

PAI-1: An Integrator of Cell Signaling and Migration

Por Czekay, Ralf-Peter, Wilkins-Port, Cynthia E., Higgins, Stephen P., Freytag, Jennifer, Overstreet, Jessica M., Klein, R. Matthew, Higgins, Craig E., Samarakoon, Rohan, Higgins, Paul J.
Publicado em 2011