Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

Epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis of diabetic nephropathy and renal fibrosis; however, the causative role of sustained EGFR activation is unclear. Here, we generated a novel kidney fibrotic mouse model of persistent EGFR activation by selectively express...

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Publicat a:FASEB J
Autors principals: Overstreet, Jessica M., Wang, Yinqiu, Wang, Xin, Niu, Aolei, Gewin, Leslie S., Yao, Bing, Harris, Raymond C., Zhang, Ming-Zhi
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602893/
https://ncbi.nlm.nih.gov/pubmed/28626027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601359RR
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