Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

Epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis of diabetic nephropathy and renal fibrosis; however, the causative role of sustained EGFR activation is unclear. Here, we generated a novel kidney fibrotic mouse model of persistent EGFR activation by selectively express...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Overstreet, Jessica M., Wang, Yinqiu, Wang, Xin, Niu, Aolei, Gewin, Leslie S., Yao, Bing, Harris, Raymond C., Zhang, Ming-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602893/
https://ncbi.nlm.nih.gov/pubmed/28626027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601359RR
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