Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

Epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis of diabetic nephropathy and renal fibrosis; however, the causative role of sustained EGFR activation is unclear. Here, we generated a novel kidney fibrotic mouse model of persistent EGFR activation by selectively express...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Overstreet, Jessica M., Wang, Yinqiu, Wang, Xin, Niu, Aolei, Gewin, Leslie S., Yao, Bing, Harris, Raymond C., Zhang, Ming-Zhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602893/
https://ncbi.nlm.nih.gov/pubmed/28626027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601359RR
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