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Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

Epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis of diabetic nephropathy and renal fibrosis; however, the causative role of sustained EGFR activation is unclear. Here, we generated a novel kidney fibrotic mouse model of persistent EGFR activation by selectively express...

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Bibliografski detalji
Izdano u:FASEB J
Glavni autori: Overstreet, Jessica M., Wang, Yinqiu, Wang, Xin, Niu, Aolei, Gewin, Leslie S., Yao, Bing, Harris, Raymond C., Zhang, Ming-Zhi
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602893/
https://ncbi.nlm.nih.gov/pubmed/28626027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601359RR
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