TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration

TGF-β signals through a receptor complex composed of 2 type I and 2 type II (TGF-βRII) subunits. We investigated the role of macrophage TGF-β signaling in fibrosis after AKI in mice with selective monocyte/macrophage TGF-βRII deletion (macrophage TGF-βRII(–/–) mice). Four weeks after injury, renal T...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Chung, Sungjin, Overstreet, Jessica M., Li, Yan, Wang, Yinqiu, Niu, Aolei, Wang, Suwan, Fan, Xiaofeng, Sasaki, Kensuke, Jin, Guan-Nan, Khodo, Stellor Nlandu, Gewin, Leslie, Zhang, Ming-Zhi, Harris, Raymond C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238749/
https://ncbi.nlm.nih.gov/pubmed/30385721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123563
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