Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair

Protein phosphatase magnesium-dependent-1A (PPM1A) dephosphorylates SMAD2/3, which suppresses TGF-β signaling in keratinocytes and during Xenopus development; however, potential involvement of PPM1A in chronic kidney disease is unknown. PPM1A expression was dramatically decreased in the tubulointers...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Samarakoon, Rohan, Rehfuss, Alexandra, Khakoo, Nidah S., Falke, Lucas L., Dobberfuhl, Amy D., Helo, Sevann, Overstreet, Jessica M., Goldschmeding, Roel, Higgins, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024688/
https://ncbi.nlm.nih.gov/pubmed/27328942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500105R
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