TGF-β1–p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

Chronic kidney disease affects >15% of the U.S. population and >850 million individuals worldwide. Fibrosis is the common outcome of many chronic renal disorders and, although the etiology varies (i.e., diabetes, hypertension, ischemia, acute injury, and urologic obstructive disorders), persis...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Higgins, Craig E., Tang, Jiaqi, Mian, Badar M., Higgins, Stephen P., Gifford, Cody C., Conti, David J., Meldrum, Kirstan K., Samarakoon, Rohan, Higgins, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766640/
https://ncbi.nlm.nih.gov/pubmed/31284746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900943R
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