Resources for the design of CRISPR gene editing experiments

由 Graham, Daniel B., Root, David E.
發表在 Genome Biol (2015)

Detecting Spatial Patterns in Biological Array Experiments

由 ROOT, DAVID E., KELLEY, BRIAN P., STOCKWELL, BRENT R.
出版 2003

Global analysis of large-scale chemical and biological experiments

由 Root, David E, Kelley, Brian P, Stockwell, Brent R
出版 2002

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease

由 Shema, Reut, Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam
發表在 Proc Natl Acad Sci U S A (2015)

Identification of an Oncogenic RAB Protein

由 Wheeler, Douglas B., Zoncu, Roberto, Root, David E., Sabatini, David M., Sawyers, Charles L.
發表在 Science (2015)

High-throughput platform for identifying molecular factors involved in phenotypic stabilization of primary human hepatocytes in vitro

由 Shan, Jing, Logan, David J., Root, David E., Carpenter, Anne E., Bhatia, Sangeeta N.
發表在 J Biomol Screen (2016)

Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors

由 Whittaker, Steven R., Cowley, Glenn S., Wagner, Steve, Luo, Flora, Root, David E., Garraway, Levi A.
發表在 Mol Cancer Ther (2015)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression

由 Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
出版 2010

Correction: Mitochondrial and nuclear genomic responses to loss of LRPPRC expression.

由 Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
發表在 J Biol Chem (2020)

Conserved pathways within bacteria and yeast as revealed by global protein network alignment

由 Kelley, Brian P., Sharan, Roded, Karp, Richard M., Sittler, Taylor, Root, David E., Stockwell, Brent R., Ideker, Trey
出版 2003

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8(+) T-cell effector differentiation

由 Godec, Jernej, Cowley, Glenn S., Barnitz, R. Anthony, Alkan, Ozan, Root, David E., Sharpe, Arlene H., Haining, W. Nicholas
發表在 Proc Natl Acad Sci U S A (2015)

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

由 Donovan, Katherine F., Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W., Johannessen, Cory M., Root, David E., Doench, John G.
發表在 PLoS One (2017)

A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer

由 Milton, Charlotte K., Self, Annette J., Clarke, Paul A., Banerji, Udai, Piccioni, Federica, Root, David E., Whittaker, Steven R.
發表在 Mol Cancer Ther (2020)

Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

由 Wagner, Joel P., Wolf-Yadlin, Alejandro, Sevecka, Mark, Grenier, Jennifer K., Root, David E., Lauffenburger, Douglas A., MacBeath, Gavin
出版 2013

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

由 Rosenbluh, Joseph, Xu, Han, Harrington, William, Gill, Stanley, Wang, Xiaoxing, Vazquez, Francisca, Root, David E., Tsherniak, Aviad, Hahn, William C.
發表在 Nat Commun (2017)

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

由 Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.
發表在 Cell Metab (2016)

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

由 Oh, Hyung Suk, Bryant, Kevin F., Nieland, Thomas J. F., Mazumder, Aprotim, Bagul, Mukta, Bathe, Mark, Root, David E., Knipe, David M.
出版 2014

High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

由 Nieland, Thomas J. F., Logan, David J., Saulnier, Jessica, Lam, Daniel, Johnson, Caroline, Root, David E., Carpenter, Anne E., Sabatini, Bernardo L.
出版 2014

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

由 Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
發表在 PLoS One (2015)

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

由 Guyon, Clotilde, Jmari, Nada, Padonou, Francine, Li, Yen-Chin, Ucar, Olga, Fujikado, Noriyuki, Coulpier, Fanny, Blanchet, Christophe, Root, David E, Giraud, Matthieu
發表在 eLife (2020)