Resources for the design of CRISPR gene editing experiments

Autor Graham, Daniel B., Root, David E.
Vydáno v Genome Biol (2015)

Detecting Spatial Patterns in Biological Array Experiments

Autor ROOT, DAVID E., KELLEY, BRIAN P., STOCKWELL, BRENT R.
Vydáno 2003

Global analysis of large-scale chemical and biological experiments

Autor Root, David E, Kelley, Brian P, Stockwell, Brent R
Vydáno 2002

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease

Autor Shema, Reut, Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam
Vydáno v Proc Natl Acad Sci U S A (2015)

Identification of an Oncogenic RAB Protein

Autor Wheeler, Douglas B., Zoncu, Roberto, Root, David E., Sabatini, David M., Sawyers, Charles L.
Vydáno v Science (2015)

High-throughput platform for identifying molecular factors involved in phenotypic stabilization of primary human hepatocytes in vitro

Autor Shan, Jing, Logan, David J., Root, David E., Carpenter, Anne E., Bhatia, Sangeeta N.
Vydáno v J Biomol Screen (2016)

Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors

Autor Whittaker, Steven R., Cowley, Glenn S., Wagner, Steve, Luo, Flora, Root, David E., Garraway, Levi A.
Vydáno v Mol Cancer Ther (2015)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression

Autor Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
Vydáno 2010

Correction: Mitochondrial and nuclear genomic responses to loss of LRPPRC expression.

Autor Gohil, Vishal M., Nilsson, Roland, Belcher-Timme, Casey A., Luo, Biao, Root, David E., Mootha, Vamsi K.
Vydáno v J Biol Chem (2020)

Conserved pathways within bacteria and yeast as revealed by global protein network alignment

Autor Kelley, Brian P., Sharan, Roded, Karp, Richard M., Sittler, Taylor, Root, David E., Stockwell, Brent R., Ideker, Trey
Vydáno 2003

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8(+) T-cell effector differentiation

Autor Godec, Jernej, Cowley, Glenn S., Barnitz, R. Anthony, Alkan, Ozan, Root, David E., Sharpe, Arlene H., Haining, W. Nicholas
Vydáno v Proc Natl Acad Sci U S A (2015)

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

Autor Donovan, Katherine F., Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W., Johannessen, Cory M., Root, David E., Doench, John G.
Vydáno v PLoS One (2017)

A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer

Autor Milton, Charlotte K., Self, Annette J., Clarke, Paul A., Banerji, Udai, Piccioni, Federica, Root, David E., Whittaker, Steven R.
Vydáno v Mol Cancer Ther (2020)

Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

Autor Wagner, Joel P., Wolf-Yadlin, Alejandro, Sevecka, Mark, Grenier, Jennifer K., Root, David E., Lauffenburger, Douglas A., MacBeath, Gavin
Vydáno 2013

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

Autor Rosenbluh, Joseph, Xu, Han, Harrington, William, Gill, Stanley, Wang, Xiaoxing, Vazquez, Francisca, Root, David E., Tsherniak, Aviad, Hahn, William C.
Vydáno v Nat Commun (2017)

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

Autor Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.
Vydáno v Cell Metab (2016)

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

Autor Oh, Hyung Suk, Bryant, Kevin F., Nieland, Thomas J. F., Mazumder, Aprotim, Bagul, Mukta, Bathe, Mark, Root, David E., Knipe, David M.
Vydáno 2014

High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

Autor Nieland, Thomas J. F., Logan, David J., Saulnier, Jessica, Lam, Daniel, Johnson, Caroline, Root, David E., Carpenter, Anne E., Sabatini, Bernardo L.
Vydáno 2014

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

Autor Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
Vydáno v PLoS One (2015)

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

Autor Guyon, Clotilde, Jmari, Nada, Padonou, Francine, Li, Yen-Chin, Ucar, Olga, Fujikado, Noriyuki, Coulpier, Fanny, Blanchet, Christophe, Root, David E, Giraud, Matthieu
Vydáno v eLife (2020)