Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

por Velkov, Tony, Roberts, Kade D, Nation, Roger L, Thompson, Philip E, Li, Jian
Publicado 2013

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

por Velkov, Tony, Roberts, Kade D., Nation, Roger L., Wang, Jiping, Thompson, Philip E., Li, Jian
Publicado 2014

Design and Evaluation of Novel Polymyxin Fluorescent Probes

por Yun, Bo, Roberts, Kade D., Thompson, Philip E., Nation, Roger L., Velkov, Tony, Li, Jian
Publicado en Sensors (Basel) (2017)

Polymyxins and analogs bind to ribosomal RNA and interfere with eukaryotic translation in vitro

por McCoy, Lisa S., Roberts, Kade D., Nation, Roger L., Thompson, Philip E., Velkov, Tony, Li, Jian, Tor, Yitzhak
Publicado 2013

Measuring Polymyxin Uptake by Renal Tubular Cells: Is BODIPY-Polymyxin B an Appropriate Probe?

por Azad, Mohammad A. K., Yun, Bo, Roberts, Kade D., Nation, Roger L., Thompson, Philip E., Velkov, Tony, Li, Jian
Publicado 2014

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

por Deris, Zakuan Z., Akter, Jesmin, Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Nation, Roger L., Li, Jian, Velkov, Tony
Publicado 2013

Imaging the distribution of polymyxins in the kidney

por Yun, Bo, Azad, Mohammad A. K., Wang, Jiping, Nation, Roger L., Thompson, Philip E., Roberts, Kade D., Velkov, Tony, Li, Jian
Publicado en J Antimicrob Chemother (2015)

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

por Lu, Xiaoxi, Chan, Ting, Xu, Chenghao, Zhu, Ling, Zhou, Qi Tony, Roberts, Kade D., Chan, Hak-Kim, Li, Jian, Zhou, Fanfan
Publicado en J Antimicrob Chemother (2016)

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria

por Roberts, Kade D., Azad, Mohammad A. K., Wang, Jiping, Horne, Andrew S, Thompson, Philip E., Nation, Roger L., Velkov, Tony, Li, Jian
Publicado en ACS Infect Dis (2015)

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

por Yun, Bo, Azad, Mohammad A. K., Nowell, Cameron J., Nation, Roger L., Thompson, Philip E., Roberts, Kade D., Velkov, Tony, Li, Jian
Publicado en Antimicrob Agents Chemother (2015)

Structure–activity relationships for the binding of polymyxins with human α-1-acid glycoprotein

por Azad, Mohammad A.K., Huang, Johnny X., Cooper, Matthew A., Roberts, Kade D., Thompson, Philip E., Nation, Roger L., Li, Jian, Velkov, Tony
Publicado 2012

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

por Zhao, Jinxin, Cheah, Soon-Ee, Roberts, Kade D., Nation, Roger L., Thompson, Philip E., Velkov, Tony, Du, Zongjun, Johnson, Matthew D., Li, Jian
Publicado en mSphere (2016)

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress

por Azad, Mohammad A. K., Sivanesan, Sivashangarie, Wang, Jiping, Chen, Ke, Nation, Roger L., Thompson, Philip E., Roberts, Kade D., Velkov, Tony, Li, Jian
Publicado en Antimicrob Agents Chemother (2017)

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

por Schneider-Futschik, Elena K., Paulin, Olivia K. A., Hoyer, Daniel, Roberts, Kade D., Ziogas, James, Baker, Mark A., Karas, John, Li, Jian, Velkov, Tony
Publicado en ACS Infect Dis (2018)

Simulations of octapeptin–outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency

por Jiang, Xukai, Yang, Kai, Yuan, Bing, Gong, Bin, Wan, Lin, Patil, Nitin A., Swarbrick, James D., Roberts, Kade D., Schreiber, Falk, Wang, Lushan, Velkov, Tony, Li, Jian
Publicado en J Biol Chem (2020)

Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria

por Deris, Zakuan Z., Swarbrick, James D., Roberts, Kade D., Azad, Mohammad A. K., Akter, Jesmin, Horne, Andrew. S., Nation, Roger L., Rogers, Kelly L., Thompson, Phillip E., Velkov, Tony, Li, Jian
Publicado 2014

Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter ba...

por Jiang, Xukai, Yang, Kai, Yuan, Bing, Han, Meiling, Zhu, Yan, Roberts, Kade D, Patil, Nitin A, Li, Jingliang, Gong, Bin, Hancock, Robert E W, Velkov, Tony, Schreiber, Falk, Wang, Lushan, Li, Jian
Publicado en J Antimicrob Chemother (2020)

Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells

por Jiang, Xukai, Zhang, Shuo, Azad, Mohammad A. K., Roberts, Kade D., Wan, Lin, Gong, Bin, Yang, Kai, Yuan, Bing, Uddin, Hemayet, Li, Jingliang, Thompson, Philip E., Velkov, Tony, Fu, Jing, Wang, Lushan, Li, Jian
Publicado en ACS Infect Dis (2020)

A novel chemical biology approach for mapping of polymyxin-lipopeptide antibody binding epitopes

por Velkov, Tony, Yun, Bo, Schneider, Elena K., Azad, Mohammad A. K., Dolezal, Olan, Morris, Faye C., Nation, Roger L., Wang, Jiping, Chen, Ke, Yu, Heidi H., Chen, Lv, Thompson, Philip E., Roberts, Kade D., Li, Jian
Publicado en ACS Infect Dis (2016)

Synchrotron-Based X-Ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells

por Azad, Mohamad A. K., Zhang, Shuo, Li, Jiayao, Kim, Yeonuk, Yu, Heidi H., Fulcher, Alex J., Howard, Daryl L., de Jonge, Martin D., James, Simon A., Roberts, Kade D., Velkov, Tony, Fu, Jing, Zhou, Qi Tony, Li, Jian
Publicado en Antimicrob Agents Chemother (2021)