Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii

BACKGROUND: MDR bacteria represent an urgent threat to human health globally. Polymyxins are a last-line therapy against life-threatening Gram-negative ‘superbugs’, including Acinetobacter baumannii. Polymyxins exert antimicrobial activity primarily via permeabilizing the bacterial outer membrane (O...

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Publicado en:J Antimicrob Chemother
Autores principales: Jiang, Xukai, Yang, Kai, Yuan, Bing, Han, Meiling, Zhu, Yan, Roberts, Kade D, Patil, Nitin A, Li, Jingliang, Gong, Bin, Hancock, Robert E W, Velkov, Tony, Schreiber, Falk, Wang, Lushan, Li, Jian
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662177/
https://ncbi.nlm.nih.gov/pubmed/32911540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa376
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