Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance

Abstract Multidrug‐resistant Acinetobacter baumannii is a top‐priority pathogen globally and polymyxins are a last‐line therapy. Polymyxin dependence in A. baumannii (i.e., nonculturable on agar without polymyxins) is a unique and highly‐resistant phenotype with a significant potential to cause trea...

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Main Authors: Yan Zhu, Jing Lu, Mei‐Ling Han, Xukai Jiang, Mohammad A. K. Azad, Nitin A. Patil, Yu‐Wei Lin, Jinxin Zhao, Yang Hu, Heidi H. Yu, Ke Chen, John D. Boyce, Rhys A. Dunstan, Trevor Lithgow, Christopher K. Barlow, Weifeng Li, Elena K. Schneider‐Futschik, Jiping Wang, Bin Gong, Bjorn Sommer, Darren J. Creek, Jing Fu, Lushan Wang, Falk Schreiber, Tony Velkov, Jian Li
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2020-08-01
Colecção:Advanced Science
Assuntos:
Acinetobacter baumannii
membrane lipidomics
molecular dynamics
polymyxin
polymyxin‐dependent resistance
Acesso em linha:https://doi.org/10.1002/advs.202000704
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