Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

Polymyxins are cyclic lipopeptide antibiotics that serve as a last line of defense against Gram-negative bacterial superbugs. However, the extensive accumulation of polymyxins in renal tubular cells can lead to nephrotoxicity, which is the major dose-limiting factor in clinical use. In order to gain...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Yun, Bo, Azad, Mohammad A. K., Nowell, Cameron J., Nation, Roger L., Thompson, Philip E., Roberts, Kade D., Velkov, Tony, Li, Jian
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2015
Ábhair:
Chemistry; Biosynthesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649194/
https://ncbi.nlm.nih.gov/pubmed/26392495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01216-15
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