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Quantitation of polymyxin-lipopolysaccharide interactions using an image-based fluorescent probe

The frequency of polymyxin-resistant pathogenic Gram-negative bacteria appearing in the clinic is increasing, and the consequences are largely mediated by modification of lipopolysaccharide (LPS) in the outer membrane. As polymyxins exert their antibacterial effect by binding to LPS, understanding t...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: McInerney, MP, Roberts, KD, Thompson, PE, Li, J, Nation, RL, Velkov, T, Nicolazzo, JA
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149457/
https://ncbi.nlm.nih.gov/pubmed/26869441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2015.10.028
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