A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Polymyxin B and colistin were examined for their ability to inhibit the type II NADH-quinone oxidoreductases (NDH-2) of three species of Gram-negative bacteria. Polymyxin B and colistin inhibited the NDH-2 activity in preparations from all of the isolates in a concentration-dependent manner. The mec...

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Autors principals: Deris, Zakuan Z., Akter, Jesmin, Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Nation, Roger L., Li, Jian, Velkov, Tony
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943757/
https://ncbi.nlm.nih.gov/pubmed/24169795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2013.111
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