Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

OBJECTIVES: Polymyxins are a last-line therapy to treat MDR Gram-negative bacterial infections. Nephrotoxicity is the dose-limiting factor for polymyxins and recent studies demonstrated significant accumulation of polymyxins in renal tubular cells. However, little is known about the mechanism of pol...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Lu, Xiaoxi, Chan, Ting, Xu, Chenghao, Zhu, Ling, Zhou, Qi Tony, Roberts, Kade D., Chan, Hak-Kim, Li, Jian, Zhou, Fanfan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710213/
https://ncbi.nlm.nih.gov/pubmed/26494147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv340
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