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A novel chemical biology approach for mapping of polymyxin-lipopeptide antibody binding epitopes

Polymyxin B and E (i.e. colistin) are a family of naturally occurring lipopeptide antibiotics that are our last-line of defense against MDR Gram-negative pathogens. Unfortunately, nephrotoxicity is a dose-limiting factor for polymyxins which limits their clinical utility. Our recent studies demonstr...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Velkov, Tony, Yun, Bo, Schneider, Elena K., Azad, Mohammad A. K., Dolezal, Olan, Morris, Faye C., Nation, Roger L., Wang, Jiping, Chen, Ke, Yu, Heidi H., Chen, Lv, Thompson, Philip E., Roberts, Kade D., Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321607/
https://ncbi.nlm.nih.gov/pubmed/27627202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00031
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