Synchrotron-Based X-Ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells

Intravenous administration of the last-line polymyxins results in poor drug exposure in the lungs and potential nephrotoxicity, whereas inhalation therapy offers better pharmacokinetics/pharmacodynamics for pulmonary infections by delivering the antibiotic directly to the infection site. However, po...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Azad, Mohamad A. K., Zhang, Shuo, Li, Jiayao, Kim, Yeonuk, Yu, Heidi H., Fulcher, Alex J., Howard, Daryl L., de Jonge, Martin D., James, Simon A., Roberts, Kade D., Velkov, Tony, Fu, Jing, Zhou, Qi Tony, Li, Jian
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2021
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092916/
https://ncbi.nlm.nih.gov/pubmed/33649114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02314-20
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