Synchrotron-Based X-Ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells

Intravenous administration of the last-line polymyxins results in poor drug exposure in the lungs and potential nephrotoxicity, whereas inhalation therapy offers better pharmacokinetics/pharmacodynamics for pulmonary infections by delivering the antibiotic directly to the infection site. However, po...

詳細記述

保存先:
書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Azad, Mohamad A. K., Zhang, Shuo, Li, Jiayao, Kim, Yeonuk, Yu, Heidi H., Fulcher, Alex J., Howard, Daryl L., de Jonge, Martin D., James, Simon A., Roberts, Kade D., Velkov, Tony, Fu, Jing, Zhou, Qi Tony, Li, Jian
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2021
主題:
Pharmacology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092916/
https://ncbi.nlm.nih.gov/pubmed/33649114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02314-20
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