Synchrotron-Based X-Ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells

Intravenous administration of the last-line polymyxins results in poor drug exposure in the lungs and potential nephrotoxicity, whereas inhalation therapy offers better pharmacokinetics/pharmacodynamics for pulmonary infections by delivering the antibiotic directly to the infection site. However, po...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Azad, Mohamad A. K., Zhang, Shuo, Li, Jiayao, Kim, Yeonuk, Yu, Heidi H., Fulcher, Alex J., Howard, Daryl L., de Jonge, Martin D., James, Simon A., Roberts, Kade D., Velkov, Tony, Fu, Jing, Zhou, Qi Tony, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092916/
https://ncbi.nlm.nih.gov/pubmed/33649114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02314-20
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