Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach

[Image: see text] Polymyxin is the last-line therapy against Gram-negative ‘superbugs’; however, dose-limiting nephrotoxicity can occur in up to 60% of patients after intravenous administration. Understanding the accumulation and concentration of polymyxin within renal tubular cells is essential for...

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Bibliographic Details
Published in:Anal Chem
Main Authors: Azad, Mohammad A. K., Roberts, Kade D., Yu, Heidi H., Liu, Boyin, Schofield, Alice V., James, Simon A., Howard, Daryl L., Nation, Roger L., Rogers, Kelly, de Jonge, Martin D., Thompson, Philip E., Fu, Jing, Velkov, Tony, Li, Jian
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318625/
https://ncbi.nlm.nih.gov/pubmed/25553489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac504516k
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