Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

Por Shillingford, Jonathan M., Piontek, Klaus B., Germino, Gregory G., Weimbs, Thomas
Publicado em 2010

Exosome - miR-335 as a novel therapeutic strategy in hepatocellular carcinoma

Por Wang, Fang, Li, Ling, Piontek, Klaus, Sakaguchi, Masazumi, Selaru, Florin M.
Publicado no Hepatology (2018)

Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures

Por Rowe, Isaline, Chiaravalli, Marco, Piontek, Klaus B., Germino, Gregory G., Boletta, Alessandra
Publicado em 2014

Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile

Por Li, Ling, Piontek, Klaus B., Kumbhari, Vivek, Ishida, Masaharu, Selaru, Florin M.
Publicado no J Vis Exp (2016)

Crystallization of a 45 kDa peroxygenase/peroxidase from the mushroom Agrocybe aegerita and structure determination by SAD utilizing only the haem iron

Por Piontek, Klaus, Ullrich, René, Liers, Christiane, Diederichs, Kay, Plattner, Dietmar A., Hofrichter, Martin
Publicado em 2010

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

Por Piontek, Klaus, Menezes, Luis F, Garcia-Gonzalez, Miguel A, Huso, David L, Germino, Gregory G
Publicado em 2007

First Crystal Structure of a Fungal High-redox Potential Dye-decolorizing Peroxidase: SUBSTRATE INTERACTION SITES AND LONG-RANGE ELECTRON TRANSFER

Por Strittmatter, Eric, Liers, Christiane, Ullrich, René, Wachter, Sabrina, Hofrichter, Martin, Plattner, Dietmar A., Piontek, Klaus
Publicado em 2013

MicroRNA-224 Induces G1/S Checkpoint Release in Liver Cancer

Por An, Fangmei, Olaru, Alexandru V., Mezey, Esteban, Xie, Qing, Li, Ling, Piontek, Klaus B., Selaru, Florin M.
Publicado no J Clin Med (2015)

Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors

Por Allen, Erica, Piontek, Klaus B., Garrett-Mayer, Elizabeth, Garcia-Gonzalez, Miguel, Gorelick, Kerry Lee, Germino, Gregory G.
Publicado em 2005

Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier

Por Menezes, Luis F., Zhou, Fang, Patterson, Andrew D., Piontek, Klaus B., Krausz, Kristopher W., Gonzalez, Frank J., Germino, Gregory G.
Publicado em 2012

Structural Basis of Substrate Conversion in a New Aromatic Peroxygenase: CYTOCHROME P450 FUNCTIONALITY WITH BENEFITS

Por Piontek, Klaus, Strittmatter, Eric, Ullrich, René, Gröbe, Glenn, Pecyna, Marek J., Kluge, Martin, Scheibner, Katrin, Hofrichter, Martin, Plattner, Dietmar A.
Publicado em 2013

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

Por Distefano, Gianfranco, Boca, Manila, Rowe, Isaline, Wodarczyk, Claas, Ma, Li, Piontek, Klaus B., Germino, Gregory G., Pandolfi, Pier Paolo, Boletta, Alessandra
Publicado em 2009

A comparative structural analysis of the surface properties of asco-laccases

Por Ernst, Heidi A., Jørgensen, Lise J., Bukh, Christian, Piontek, Klaus, Plattner, Dietmar A., Østergaard, Lars H., Larsen, Sine, Bjerrum, Morten J.
Publicado no PLoS One (2018)

Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts

Por Paul, Binu M., Vassmer, Dianne, Taylor, Aaron, Magenheimer, Lynn, Carlton, Carol G., Piontek, Klaus B., Germino, Gregory G., Vanden Heuvel, Gregory B.
Publicado em 2011

Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression

Por WISSING, MICHEL D., DADON, TIKVA, KIM, EUNICE, PIONTEK, KLAUS B., SHIM, JOONG S., KAELBER, NADINE S., LIU, JUN O., KACHHAP, SUSHANT K., NELKIN, BARRY D.
Publicado em 2014

Successful liver-directed gene delivery by ERCP-guided hydrodynamic injection (with videos)

Por Kumbhari, Vivek, Li, Ling, Piontek, Klaus, Ishida, Masaharu, Fu, Rongdang, Khalil, Bassem, Garrett, Caroline M., Liapi, Eleni, Kalloo, Anthony N., Selaru, Florin M.
Publicado no Gastrointest Endosc (2018)

Inactivation of Pkd1 in principal cells causes more severe cystic kidney disease than in intercalated cells

Por Raphael, Kalani L., Strait, Kevin A., Stricklett, Peter K., Miller, R. Lance, Nelson, Raoul D., Piontek, Klaus B., Germino, Gregory G., Kohan, Donald E.
Publicado em 2009

Pkd1 Haploinsufficiency Increases Renal Damage and Induces Microcyst Formation following Ischemia/Reperfusion

Por Bastos, Ana P., Piontek, Klaus, Silva, Ana M., Martini, Dino, Menezes, Luis F., Fonseca, Jonathan M., Fonseca, Ivone I., Germino, Gregory G., Onuchic, Luiz F.
Publicado em 2009

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure

Por Yu, Shengqiang, Hackmann, Karl, Gao, Jianggang, He, Xiaobing, Piontek, Klaus, García González, Miguel A., Menezes, Luis F., Xu, Hangxue, Germino, Gregory G., Zuo, Jian, Qian, Feng
Publicado em 2007

Pkd1 and Pkd2 Are Required for Normal Placental Development

Por Garcia-Gonzalez, Miguel A., Outeda, Patricia, Zhou, Qin, Zhou, Fang, Menezes, Luis F., Qian, Feng, Huso, David L., Germino, Gregory G., Piontek, Klaus B., Watnick, Terry
Publicado em 2010