Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure

Polycystin-1 (PC1) has an essential function in renal tubular morphogenesis and disruption of its function causes cystogenesis in human autosomal dominant polycystic kidney disease. We have previously shown that recombinant human PC1 is cis-autoproteolytically cleaved at the G protein-coupled recept...

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Main Authors: Yu, Shengqiang, Hackmann, Karl, Gao, Jianggang, He, Xiaobing, Piontek, Klaus, García González, Miguel A., Menezes, Luis F., Xu, Hangxue, Germino, Gregory G., Zuo, Jian, Qian, Feng
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141838/
https://ncbi.nlm.nih.gov/pubmed/18003909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708217104
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