Pkd1 Haploinsufficiency Increases Renal Damage and Induces Microcyst Formation following Ischemia/Reperfusion

Mutations in PKD1 cause the majority of cases of autosomal dominant polycystic kidney disease (ADPKD). Because polycystin 1 modulates cell proliferation, cell differentiation, and apoptosis, its lower biologic activity observed in ADPKD might influence the degree of injury after renal ischemia/reper...

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Bibliographic Details
Main Authors: Bastos, Ana P., Piontek, Klaus, Silva, Ana M., Martini, Dino, Menezes, Luis F., Fonseca, Jonathan M., Fonseca, Ivone I., Germino, Gregory G., Onuchic, Luiz F.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2009
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799174/
https://ncbi.nlm.nih.gov/pubmed/19833899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008040435
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