Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression

Cyclin-dependent kinase 5 (CDK5) is a potential target for prostate cancer treatment, the enzyme being essential for prostate tumor growth and formation of metastases. In the present study, we identified agents that target prostate cancer cells based on CDK5 expression. CDK5 activity was suppressed...

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Main Authors: WISSING, MICHEL D., DADON, TIKVA, KIM, EUNICE, PIONTEK, KLAUS B., SHIM, JOONG S., KAELBER, NADINE S., LIU, JUN O., KACHHAP, SUSHANT K., NELKIN, BARRY D.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067428/
https://ncbi.nlm.nih.gov/pubmed/24841903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2014.3174
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