Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression

Cyclin-dependent kinase 5 (CDK5) is a potential target for prostate cancer treatment, the enzyme being essential for prostate tumor growth and formation of metastases. In the present study, we identified agents that target prostate cancer cells based on CDK5 expression. CDK5 activity was suppressed...

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Hoofdauteurs: WISSING, MICHEL D., DADON, TIKVA, KIM, EUNICE, PIONTEK, KLAUS B., SHIM, JOONG S., KAELBER, NADINE S., LIU, JUN O., KACHHAP, SUSHANT K., NELKIN, BARRY D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: D.A. Spandidos 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067428/
https://ncbi.nlm.nih.gov/pubmed/24841903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2014.3174
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