Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells

The N-myc downstream regulated gene 1 (NDRG1) has been identified as a metastasis-suppressor gene in prostate cancer (PCa). Compounds targeting PCa cells deficient in NDRG1 could potentially decrease invasion/metastasis of PCa. A cell based screening strategy was employed to identify small molecules...

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Detalhes bibliográficos
Main Authors: Wissing, Michel D., Mendonca, Janet, Kim, Eunice, Kim, Eugene, Shim, Joong S., Kaelber, Nadine S., Kant, Huub, Hammers, Hans, Commes, Therese, Van Diest, Paul J., Liu, Jun O., Kachhap, Sushant K.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672184/
https://ncbi.nlm.nih.gov/pubmed/23377825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.23759
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