Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier

Autosomal Dominant Polycystic Kidney Disease (ADPKD; MIM ID's 173900, 601313, 613095) leads to end-stage kidney disease, caused by mutations in PKD1 or PKD2. Inactivation of Pkd1 before or after P13 in mice results in distinct early- or late-onset disease. Using a mouse model of ADPKD carrying...

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Detalhes bibliográficos
Main Authors: Menezes, Luis F., Zhou, Fang, Patterson, Andrew D., Piontek, Klaus B., Krausz, Kristopher W., Gonzalez, Frank J., Germino, Gregory G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510057/
https://ncbi.nlm.nih.gov/pubmed/23209428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003053
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