Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome : Differential Effects of APOE Genotype and Presenilin Mutations

Por Cataldo, Anne M., Peterhoff, Corrinne M., Troncoso, Juan C., Gomez-Isla, Teresa, Hyman, Bradley T., Nixon, Ralph A.
Publicado em 2000

The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models

Por Dyakin, Victor V., Chen, Yuanxin, Branch, Craig A., Veeranna, Yuan, Aidong, Rao, Mala, Kumar, Asok, Peterhoff, Corrinne M., Nixon, Ralph. A
Publicado em 2010

Peripherin Is a Subunit of Peripheral Nerve Neurofilaments: Implications for Differential Vulnerability of CNS and Peripheral Nervous System Axons

Por Yuan, Aidong, Sasaki, Takahiro, Kumar, Asok, Peterhoff, Corrinne M., Rao, Mala V., Liem, Ronald K., Julien, Jean-Pierre, Nixon, Ralph A.
Publicado em 2012

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Por Bordi, Matteo, Berg, Martin J., Mohan, Panaiyur S., Peterhoff, Corrinne M., Alldred, Melissa J., Che, Shaoli, Ginsberg, Stephen D., Nixon, Ralph A.
Publicado no Autophagy (2016)

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology : Accelerated Endocytosis Promotes Late Endocytic Defects

Por Cataldo, Anne M., Mathews, Paul M., Boiteau, Anne Boyer, Hassinger, Linda C., Peterhoff, Corrinne M., Jiang, Ying, Mullaney, Kerry, Neve, Rachael L., Gruenberg, Jean, Nixon, Ralph A.
Publicado em 2008

Alzheimer’s-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition

Por Jiang, Ying, Mullaney, Kerry A., Peterhoff, Corrinne M., Che, Shaoli, Schmidt, Stephen D., Boyer-Boiteau, Anne, Ginsberg, Stephen D., Cataldo, Anne M., Mathews, Paul M., Nixon, Ralph A.
Publicado em 2009

Partial BACE1 Reduction in a Down Syndrome Mouse Model blocks Alzheimer-related Endosomal Anomalies and Cholinergic Neurodegeneration: Role of APP-CTF

Por Jiang, Ying, Rigoglioso, Andrew, Peterhoff, Corrinne M., Pawlik, Monika, Sato, Yutaka, Bleiwas, Cynthia, Stavrides, Philip, Smiley, John F., Ginsberg, Stephen D., Mathews, Paul M., Levy, Efrat, Nixon, Ralph A.
Publicado no Neurobiol Aging (2015)

Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

Por Rao, Mala V., Mohan, Panaiyur S., Peterhoff, Corrinne M., Yang, Dun-Sheng, Schmidt, Stephen D., Stavrides, Philip H., Campbell, Jabbar, Chen, Yuanxin, Jiang, Ying, Paskevich, Peter A., Cataldo, Anne M., Haroutunian, Vahram, Nixon, Ralph A.
Publicado em 2008

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Por Lee, Ju-Hyun, Yu, W. Haung, Kumar, Asok, Lee, Sooyeon, Mohan, Panaiyur S., Peterhoff, Corrinne M., Wolfe, Devin M., Martinez-Vicente, Marta, Massey, Ashish C., Sovak, Guy, Uchiyama, Yasuo, Westaway, David, Sisodia, Sangram S., Cuervo, Ana Maria, Nixon, Ralph A.
Publicado em 2010

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

Por Yu, W. Haung, Cuervo, Ana Maria, Kumar, Asok, Peterhoff, Corrinne M., Schmidt, Stephen D., Lee, Ju-Hyun, Mohan, Panaiyur S., Mercken, Marc, Farmery, Mark R., Tjernberg, Lars O., Jiang, Ying, Duff, Karen, Uchiyama, Yasuo, Näslund, Jan, Mathews, Paul M., Cataldo, Anne M., Nixon, Ralph A.
Publicado em 2005

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

Por Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S., Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D., Wesson, Daniel, Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M., Yang, Austin J., Wilson, Donald A., St George-Hyslop, Peter, Westaway, David, Mathews, Paul M., Levy, Efrat, Cuervo, Ana M., Nixon, Ralph A.
Publicado em 2011

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

Por Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S, Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D, Wesson, Daniel W, Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M, Yang, Austin J, Wilson, Donald A, St George-Hyslop, Peter, Westaway, David, Mathews, Paul M, Levy, Efrat, Cuervo, Ana M, Nixon, Ralph A
Publicado em 2011