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Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome : Differential Effects of APOE Genotype and Presenilin Mutations
Endocytosis is critical to the function and fate of molecules important to Alzheimer’s disease (AD) etiology, including the β protein precursor (βPP), amyloid β (Aβ) peptide, and apolipoprotein E (ApoE). Early endosomes, a major site of Aβ peptide generation, are markedly enlarged within neurons in...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Investigative Pathology
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1850219/ https://ncbi.nlm.nih.gov/pubmed/10880397 |
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