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Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology : Accelerated Endocytosis Promotes Late Endocytic Defects
Endocytic dysfunction is an early pathological change in Alzheimer’s disease (AD) and Down’s syndrome (DS). Using primary fibroblasts from DS individuals, we explored the interactions among endocytic compartments that are altered in AD and assessed their functional consequences in AD pathogenesis. W...
Tallennettuna:
| Päätekijät: | , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Investigative Pathology
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2475775/ https://ncbi.nlm.nih.gov/pubmed/18535180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071053 |
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