Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology : Accelerated Endocytosis Promotes Late Endocytic Defects

Endocytic dysfunction is an early pathological change in Alzheimer’s disease (AD) and Down’s syndrome (DS). Using primary fibroblasts from DS individuals, we explored the interactions among endocytic compartments that are altered in AD and assessed their functional consequences in AD pathogenesis. W...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Cataldo, Anne M., Mathews, Paul M., Boiteau, Anne Boyer, Hassinger, Linda C., Peterhoff, Corrinne M., Jiang, Ying, Mullaney, Kerry, Neve, Rachael L., Gruenberg, Jean, Nixon, Ralph A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Investigative Pathology 2008
Aiheet:
Regular Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475775/
https://ncbi.nlm.nih.gov/pubmed/18535180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071053
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia