Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology : Accelerated Endocytosis Promotes Late Endocytic Defects

Endocytic dysfunction is an early pathological change in Alzheimer’s disease (AD) and Down’s syndrome (DS). Using primary fibroblasts from DS individuals, we explored the interactions among endocytic compartments that are altered in AD and assessed their functional consequences in AD pathogenesis. W...

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Autors principals: Cataldo, Anne M., Mathews, Paul M., Boiteau, Anne Boyer, Hassinger, Linda C., Peterhoff, Corrinne M., Jiang, Ying, Mullaney, Kerry, Neve, Rachael L., Gruenberg, Jean, Nixon, Ralph A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2008
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475775/
https://ncbi.nlm.nih.gov/pubmed/18535180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071053
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