Partial BACE1 Reduction in a Down Syndrome Mouse Model blocks Alzheimer-related Endosomal Anomalies and Cholinergic Neurodegeneration: Role of APP-CTF

β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly implicated in Alzheimer's disease (AD) pathogenesis, although recent evidence has linked APP-βCTF generated by BACE1 (β-APP cleaving enzyme 1) to the development of endocytic abnormalities and cholinergic neurodegenera...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Jiang, Ying, Rigoglioso, Andrew, Peterhoff, Corrinne M., Pawlik, Monika, Sato, Yutaka, Bleiwas, Cynthia, Stavrides, Philip, Smiley, John F., Ginsberg, Stephen D., Mathews, Paul M., Levy, Efrat, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773919/
https://ncbi.nlm.nih.gov/pubmed/26923405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.11.013
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