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Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing
The β-site APP cleaving enzyme-1 (BACE1) mediates the first cleavage of the β-amyloid precursor protein (APP) to yield the amyloid β-peptide (Aβ), a key pathogenic agent in Alzheimer’s disease (AD). Using a proteomic approach based on in-cell chemical cross-linking and tandem affinity purification (...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Federation of American Societies for Experimental Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909280/ https://ncbi.nlm.nih.gov/pubmed/20354142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-146357 |
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