Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

The β-site APP cleaving enzyme-1 (BACE1) mediates the first cleavage of the β-amyloid precursor protein (APP) to yield the amyloid β-peptide (Aβ), a key pathogenic agent in Alzheimer’s disease (AD). Using a proteomic approach based on in-cell chemical cross-linking and tandem affinity purification (...

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Detaylı Bibliyografya
Asıl Yazarlar: Okada, Hirokazu, Zhang, Wenzhu, Peterhoff, Corrinne, Hwang, Jeremy C., Nixon, Ralph A., Ryu, Sung H., Kim, Tae-Wan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Federation of American Societies for Experimental Biology 2010
Konular:
Research Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909280/
https://ncbi.nlm.nih.gov/pubmed/20354142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-146357
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