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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
BACKGROUND: β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular trafficking of BACE1 may affect Aβ generation, contributing to AD pathology. In t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3439308/ https://ncbi.nlm.nih.gov/pubmed/22709416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-30 |
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