Alzheimer’s-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition

An additional copy of the β-amyloid precursor protein (APP) gene causes early-onset Alzheimer’s disease (AD) in trisomy 21 (DS). Endosome dysfunction develops very early in DS and AD and has been implicated in the mechanism of neurodegeneration. Here, we show that morphological and functional endocy...

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Detalhes bibliográficos
Main Authors: Jiang, Ying, Mullaney, Kerry A., Peterhoff, Corrinne M., Che, Shaoli, Schmidt, Stephen D., Boyer-Boiteau, Anne, Ginsberg, Stephen D., Cataldo, Anne M., Mathews, Paul M., Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824382/
https://ncbi.nlm.nih.gov/pubmed/20080541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908953107
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