In Vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model

In vivo quantitative magnetic resonance imaging (MRI) was employed to detect brain pathology and map its distribution within control, disomic mice (2N) and in Ts65Dn and Ts1Cje trisomy mice with features of human Down syndrome (DS). In Ts65Dn, but not Ts1Cje mice, transverse proton spin-spin (T(2))...

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Hlavní autoři: Chen, Yuanxin, Dyakin, Victor V., Branch, Craig A., Ardekani, Babak, Yang, Dunsheng, Guilfoyle, David N., Peterson, Jesse, Peterhoff, Corrinne, Ginsberg, Stephen D., Cataldo, Anne M., Nixon, Ralph A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771203/
https://ncbi.nlm.nih.gov/pubmed/18180075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.11.026
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