App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome

Altered neuronal endocytosis is the earliest known pathology in sporadic Alzheimer's disease (AD) and Down syndrome (DS) brain and has been linked to increased Aβ production. Here, we show that a genetic model of DS (trisomy 21), the segmental trisomy 16 mouse Ts65Dn, develops enlarged neuronal...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Cataldo, Anne M., Petanceska, Suzana, Peterhoff, Corrinne M., Terio, Nicole B., Epstein, Charles J., Villar, Angela, Carlson, Elaine J., Staufenbiel, Matthias, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740714/
https://ncbi.nlm.nih.gov/pubmed/12890772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-17-06788.2003
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