Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer’s Disease

Mechanisms of neuronal loss in Alzheimer’s disease (AD) are poorly understood. Here we show that apoptosis is a major form of neuronal cell death in PS/APP mice modeling AD-like neurodegeneration. Pyknotic neurons in adult PS/APP mice exhibited apoptotic changes, including DNA fragmentation, caspase...

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Detalhes bibliográficos
Main Authors: Yang, Dun-Sheng, Kumar, Asok, Stavrides, Philip, Peterson, Jesse, Peterhoff, Corrine M., Pawlik, Monika, Levy, Efrat, Cataldo, Anne M., Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527090/
https://ncbi.nlm.nih.gov/pubmed/18688038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071176
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