Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

Autophagy, a major degradative pathway for proteins and organelles, is essential for survival of mature neurons. Extensive autophagic-lysosomal pathology in Alzheimer’s disease brain contributes to Alzheimer’s disease pathogenesis, although the underlying mechanisms are not well understood. Here, we...

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Main Authors: Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S., Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D., Wesson, Daniel, Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M., Yang, Austin J., Wilson, Donald A., St George-Hyslop, Peter, Westaway, David, Mathews, Paul M., Levy, Efrat, Cuervo, Ana M., Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009842/
https://ncbi.nlm.nih.gov/pubmed/21186265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awq341
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