Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is markedly impaired in neurons in Alzheimer’s disease and Alzheimer mouse models. We have previously reported that severe lysosomal and amyloid neuropathology and associated cognitive deficits in the TgCRND8 Alzheim...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Yang, Dun-Sheng, Stavrides, Philip, Saito, Mitsuo, Kumar, Asok, Rodriguez-Navarro, Jose A., Pawlik, Monika, Huo, Chunfeng, Walkley, Steven U., Saito, Mariko, Cuervo, Ana M., Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240291/
https://ncbi.nlm.nih.gov/pubmed/25270989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu278
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