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Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy

OBJECTIVE—To clarify the phenotypic heterogeneity in deposition of amyloid beta (Aβ) in the parenchyma and in cerebral vessels of the brains of the patients having presenilin-1 (PS1) mutations. Mutations in PS1 induce increased production of Aβ42(43), resulting in an enhanced overall deposition of A...

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Detaylı Bibliyografya
Asıl Yazarlar: Yasuda, M., Maeda, S., Kawamata, T., Tamaoka, A., Yamamoto, Y., Kuroda, S., Maeda, K., Tanaka, C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMJ Group 2000
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1736762/
https://ncbi.nlm.nih.gov/pubmed/10644793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp.68.2.220
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