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Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy

OBJECTIVE—To clarify the phenotypic heterogeneity in deposition of amyloid beta (Aβ) in the parenchyma and in cerebral vessels of the brains of the patients having presenilin-1 (PS1) mutations. Mutations in PS1 induce increased production of Aβ42(43), resulting in an enhanced overall deposition of A...

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Detalhes bibliográficos
Main Authors: Yasuda, M., Maeda, S., Kawamata, T., Tamaoka, A., Yamamoto, Y., Kuroda, S., Maeda, K., Tanaka, C.
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1736762/
https://ncbi.nlm.nih.gov/pubmed/10644793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp.68.2.220
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