Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

The presenilins (PSs) are components of large molecular complexes that contain β-catenin and function as γ-secretase. We report here a striking correlation between amyloid angiopathy and the location of mutation in PS-1 linked Alzheimer’s disease. The amount of amyloid β protein, Aβ(42(43)), but not...

Full description

Saved in:
Bibliographic Details
Main Authors: Mann, David M. A., Pickering-Brown, Stuart M., Takeuchi, Ayano, Iwatsubo, Takeshi
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2001
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891993/
https://ncbi.nlm.nih.gov/pubmed/11395394
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items