Age-Related Amyloid β Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid β Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss

To analyze the relationship between the deposition of amyloid β peptides (Aβ) and neuronal loss in transgenic models of Alzheimer’s disease (AD), we examined the frontal neocortex (Fc) and CA1 portion of hippocampus (CA1) in PSAPP mice doubly expressing AD-associated mutant presenilin 1 (PS1) and Sw...

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Detalhes bibliográficos
Main Authors: Takeuchi, Ayano, Irizarry, Michael C., Duff, Karen, Saido, Takaomi C., Hsiao Ashe, Karen, Hasegawa, Masato, Mann, David M. A., Hyman, Bradley T., Iwatsubo, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2000
Assuntos:
Animal Model
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850215/
https://ncbi.nlm.nih.gov/pubmed/10880403
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