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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

The formation of beta-amyloid in the brains of individuals with Alzheimer disease requires the proteolytic cleavage of a membrane-associated precursor protein. The proteases that may be involved in this process have not yet been identified. Cathepsins are normally intracellular proteolytic enzymes a...

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Detalhes bibliográficos
Main Authors: Cataldo, A M, Nixon, R A
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC54003/
https://ncbi.nlm.nih.gov/pubmed/1692625
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