Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.
The formation of beta-amyloid in the brains of individuals with Alzheimer disease requires the proteolytic cleavage of a membrane-associated precursor protein. The proteases that may be involved in this process have not yet been identified. Cathepsins are normally intracellular proteolytic enzymes a...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54003/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1692625/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.10.3861 |
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