Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Defective autophagy contributes to Alzheimer disease (AD) pathogenesis although evidence is conflicting on whether multiple stages are impaired. Here, for the first time, we have comprehensively evaluated the entire autophagic process specifically in CA1 pyramidal neurons of hippocampus from early a...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Bordi, Matteo, Berg, Martin J., Mohan, Panaiyur S., Peterhoff, Corrinne M., Alldred, Melissa J., Che, Shaoli, Ginsberg, Stephen D., Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173282/
https://ncbi.nlm.nih.gov/pubmed/27813694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1239003
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